MDMA Ecstasy Molly National Institute on Drug Abuse NIDA

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Upon a single administration, it takes about 1 month for the tolerance to be reduced to half and 2.5 months to be back at baseline (in the absence of further consumption). It is strongly recommended that one use harm reduction practices when using this substance. Diuretics such as alcohol may exacerbate these risks further due to causing excessive amounts of dehydration. Users are advised to pay close attention to their water intake, drinking neither too much nor too little, and to take care not to overexert themselves to avoid heat-stroke, which can be fatal. Crystals or powder (commonly called Molly) is a white to brownish substance which can be dissolved, crushed, put into gel capsules or edible paper (“parachutes”).

Thanks to the work of Rick Doblin and other scientists, MDMA will soon be legalized for its therapeutic effects. MDMA is illegal, and there are reports that it can have negative health effects. Since MDMA is currently an illegal substance, many reports about its health effects are anecdotal, and study results are often controversial. The Food and Drug Administration (FDA) has designated MDMA-assisted psychotherapy for people with PTSD as a breakthrough therapy. There are ongoing clinical studies to test how well this treatment might work.

Negative

• It has been available as a street drug since the 1980s, and use escalated in the 1990s among college students and young adults.
• The drug’s rewarding effects vary with the individual taking it, the dose taken, purity of the MDMA, and the environment in which it is taken.
• After the trip, your brain will be depleted of serotonin, dopamine, and norepinephrine.
• In the United Kingdom, MDMA was made illegal in 1977 by a modification order to the existing Misuse of Drugs Act 1971.
• In addition to this, MDMA contains a methyl substitution on RN, a feature it shares with methamphetamine.
• In the case of MDMA, it is MDMA.HCl, amphetamine is usually amphetamine.H2SO4 and LSD is LSD.tartrate.

Taking an adulterated drug can lead to unexpected and unwelcome side effects and may increase its potential health risks. Over the past decade, illegally made opioids like fentanyl have been increasingly found in the drug supply, and have contributed to a dramatic rise in drug overdose deaths in the United States. After you take the drug, your brain releases dopamine, serotonin, oxytocin, norepinephrine, and other happy chemicals. MDMA is an illegal drug that acts as both a stimulant and psychedelic, producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile experiences. MDMA is a Schedule I substance under the Controlled Substances Act, which means that the DEA has determined that it has no medical benefit and a high potential for abuse.

Why choose MDMA over other psychedelics?

MDMA has been shown to cause sexual dysfunction, including erectile dysfunction and delayed orgasm (see subjective effects). MDMA is typically produced and consumed in its racemic form (known as SR-MDMA) which consists of equal parts S-MDMA and R-MDMA. A 2017 study found that high doses of R-MDMA administered in mice increased prosocial behavior and facilitated fear-extinction learning but did not produce hyperthermia or signs of neurotoxicity.

Effects

Critically, the MDMA molecule also contains substitutions at R3 and R4 of the phenyl ring with oxygen groups — these oxygen groups are incorporated into a methylenedioxy ring through a methylene bridge. MDMA shares this methylenedioxy ring with other entactogens and stimulants like MDA, MDEA and MDAI. There are some studies which suggest that long-term overuse and abuse of MDMA can cause or increase depression.

• Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
• Do not take MDMA more than once a month if you value your brain health and mental well-being.
• Over the past decade, illegally made opioids like fentanyl have been increasingly found in the drug supply, and have contributed to a dramatic rise in drug overdose deaths in the United States.
• The logos may be produced to coincide with holidays or special events.
• However, because MDMA affects brain chemicals, some researchers think it could have lasting effects on areas, such as cognition and mood.
• Research in animals indicates that MDMA is neurotoxic and may affect the brain.
• Information provided by NIDA is not a substitute for professional medical care or legal consultation.

Recreational

Damage to brain serotonin neurons can occur; serotonin is thought to play a role in regulating mood, memory, sleep, and appetite. Studies are conflicting on MDMA use and its affects on memory and cognition. Because use promotes trust, closeness, empathy, and enhances sexual desire, the risk of unsafe sexual practices may increase, resulting in HIV/AIDS, hepatitis, or other sexually transmitted diseases. The emergency and referral resources listed above are available to individuals located in the United States and are not operated by the National Institute on Drug Abuse (NIDA).

How to cope with a bad trip

The logos may be produced to coincide with holidays or special events. Among the more popular logos are butterflies, lightning bolts, and four-leaf clovers. MDMA was first synthesized by a German company in 1912, possibly to be used as an wiki mdma appetite suppressant. It has been available as a street drug since the 1980s, and use escalated in the 1990s among college students and young adults. Then, it was most often distributed at late-night parties called “raves”, nightclubs, and rock concerts.

It’s part of a wider group of chemicals called phenethylamines, known for their hallucinogenic and stimulant effects. The drugs methamphetamine and cathinone (bath salts) are also part of this group. While the combination of Ecstasy with one or more of these drugs may be inherently dangerous, users might also voluntarily combine them with substances, such as marijuana, alcohol, or opioids, putting themselves at further risk of physical harm, overdose, or death. Users may encounter problems similar to those experienced by amphetamine and cocaine users, including addiction. Research has shown that animals will self-administer MDMA, an indicator of a drug’s abuse potential.

This is thought to owe itself to the lower dopamine release R-MDMA displays relative to SR-MDMA. This result suggests that R-MDMA may be a safer and more viable therapeutic than racemic MDMA.55 However, more research is needed to validate this finding. MDMA (an abbreviation of 3,4-methylenedioxymethamphetamine), also called “Molly” or “Ecstasy,” is a lab-made (synthetic) drug that has effects similar to stimulants like methamphetamine.

Pills vs. Powder

In most countries, you can legally buy some of them for chemical purposes.More on research chemicals below. When used in a therapeutic setting, MDMA may enhance many aspects of talk therapy. Repeated studies show that MDMA can make it easier for someone to approach therapy with vulnerability and an open mind.

After the trip, your brain will be depleted of serotonin, dopamine, and norepinephrine. When this happens, you may have to suffer through a period of not having enough of these happy chemicals.During the crash, people feel extremely depressed and have no motivation to do anything. Many MDMA users report having suicidal thoughts.This period usually lasts a few days but can sometimes take weeks or even months. MDMA (3,4-methylenedioxy-N-Methylamphetamine) is an popular drug of the phenethylamine and amphetamine class known for its empathogenic, euphoric, and stimulant effects, and has also been used in psychotherapy.